Review Article
Emerging Role of Histone Acetyltransferase in Stem Cells and Cancer
Table 3
Involvement of HAT in stem cells.
| HAT | Target | Effect in normal stem cells | Ref |
| CBP | | Maintenance of self-renewal hematopoietic stem cells | [61] |
| p300 | OCT4, SOX2, KLF4 | Stem cell reprogramming | [54] | | Proliferation and odontogenic differentiation of human dental pulp cells | [56] | | Self-renewal and pluripotency maintenance in ESCs | [57] | | Proper hematopoietic differentiation | [61] |
| GCN5 | Myc | Early reprogramming initiation in mouse PSC | [62] | NF-κB | Osteogenic commitment of mesenchymal stem cells | [64] | DKK1 | Osteogenic differentiation of periodontal ligament stem cells | [65] |
| pCAF | BMPs | Osteogenic differentiation of mesenchymal stem cells | [66] |
| MOF | NANOG, OCT4, SOX2 | Maintenance of ESC self-renewal and pluripotency | [68] | | Stem cell reprogramming | [69] |
| Tip60 | | ESC differentiation into mesoderm and endoderm lineages | [71] |
| MOZ | p16(INK4a) | Maintenance of proliferation in hematopoietic and neural stem cells | [72] |
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