Biomaterial Engineering for Controlling Pluripotent Stem Cell Fate

Table 2

ECM-derived proteins/peptides used within PSC culture systems to control cell fate.

	ECM protein/peptide	Immobilization chemistry	Lineage
Proteins	Vitronectin	Polydopamine immobilization	Pluripotency [18, 30, 43]; Reprogramming [18]
	Collagen IV	EDC conjugation	Vascular [34]; Primordial germ cells [36]
	Heparin	EDC conjugation	Pluripotency [21]; Neural [7]
Peptides	Laminin peptide (IKVAV)	Photochemistry	Neural [13, 14]
	Laminin peptide (YIGSR)	Photochemistry	Neural [14]
	Laminin 5 peptide (Ln5-P4); PPFLMLLKGSTR	EDC conjugation	Neural [3]
	Fibronectin peptide; (RGD)	Photochemistry; EDC conjugation	Neural [3, 14]; Retinal [16]; Hepatocytic [17]; Pluripotency [18]; Osteogenic [19]; Vascular [20]
	Vitronectin peptide GGPQVTRGDVFTMP	EDC conjugation	Hepatocytic [17]; Pluripotency [43–45]; Osteogenic [30, 45]
	MMP degradable peptide; GCRDV̲P̲M̲S̲↓̲M̲R̲G̲G̲DRCG	Photochemistry	Pluripotency [14]