Review Article
Biomaterial Engineering for Controlling Pluripotent Stem Cell Fate
Table 3
Biomaterials and controlled stiffness to modulate PSC fate.
| | Material | Variables to modulate stiffness | Stiffness range | Lineage studied |
| Natural | Fibrin | Precursor concentration | Pa | Endoderm [25] | Fibroblast-derived matrix | Crosslinking concentration | Pa–KPa | Pluripotency [31] | Alginate | Crosslinking concentration | KPa | Pancreatic [72] | Synthetic | PDMS | Precursor concentration | KPa–MPa | Endo-meso-ectoderm [59] Pluripotency [58] Vascular [60] | Polyacrylamide | Precursor concentration | Pa–KPa | Neural [67] Cellular reprogramming [66] | PEG hydrogel | Precursor concentration | KPa–MPa | Vascular [39] |
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