IGF-1-Overexpressing Mesenchymal Stem/Stromal Cells Promote Immunomodulatory and Proregenerative Effects in Chronic Experimental Chagas Disease

Figure 6

Quantification of inflammatory infiltrates and fibrosis area in the skeletal muscle. Representative images of skeletal muscle sections stained by conventional H&E stain for analysis of inflammatory infiltrates in naïve (a) or infected mice submitted to treatment with saline (b), MSCs (c), or MSC_IGF-1 (d). Representative images of Sirius Red staining for quantification of the fibrosis area in the skeletal muscle of naïve (e) or infected mice submitted to treatment with saline (f), MSCs (g), or MSC_IGF-1 (h). . Quantification of inflammatory cells by morphometry (i) and evaluation of Ptprc expression by RT-qPCR (j). (k) Percentage of the fibrosis area quantified by analysis of whole sections stained with Sirius Red-stained skeletal muscle. Data represent the of 5–7 mice per group. , , , and .

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