Intravenous Transplantation of Mesenchymal Stem Cells Reduces the Number of Infiltrated Ly6C⁺ Cells but Enhances the Proportions Positive for BDNF, TNF-1α, and IL-1β in the Infarct Cortices of dMCAO Rats

Figure 8

BDNF-producing cells do not overlap with TNF-α-or IL-1b-expressing cells at day 2. (a–d) Distribution of BDNF⁺ cells and IL-β⁺ cells in the infarct areas after MSC transplantation. (e–h) Distribution of BDNF⁺ cells and TNF-α⁺ cells in the infarct area after MSC transplantation. (a, e) BDNF staining. (b) IL-β. (f) TNF-α. (c, g) DAPI nucleus staining. (d) No double-stained BDNF⁺/IL-β⁺ cells were found in the infarct area after dMCAO. (h) No BDNF⁺/TNF-α⁺ cells were found 2 days after MSC transplantation in the striatum and corpus callosum after MSC transplantation. Scale bar, 250 μm.