Mathematical Modeling Reveals the Role of Hypoxia in the Promotion of Human Mesenchymal Stem Cell Long-Term Expansion

Figure 1

Schematic representation of the two-compartment model. This model conceptualizes the transition of MSCs from the originally dividing state to the ultimately nondividing state . Cells in both states may die due to internal or external stimuli. is the division rate, while and are the death rate of cells in the two states, respectively, all treated as constants. is the time-varying state transition rate.