Mathematical Modeling Reveals the Role of Hypoxia in the Promotion of Human Mesenchymal Stem Cell Long-Term Expansion

Table 2

Model parameter values for normoxic and hypoxic conditions fitted from data in experiment B. : net expansion rate;: death rate of nondividing cells; , , and are the upper bound, the steepness, and the midpoint time of the logistic state transition rate , respectively.

Parameter	Normoxia	Hypoxia
(day^−1)	0.4679^†	0.4679^†
(day^−1)	0.0286	0.0286^‡
(day^−1)	0.5864	0.5864^‡
	0.0404	0.15^§
(day)	79.0046	?^¶

^†Fitted from hypoxic data using linear regression and set under normoxia equal to the one for hypoxia. ^‡Set equal to their counterparts under normoxia. ^§Tuned manually to fit the hypoxic data. ^¶To be determined.