Chemical Activation of the Hypoxia-Inducible Factor Reversibly Reduces Tendon Stem Cell Proliferation, Inhibits Their Differentiation, and Maintains Cell Undifferentiation

<div>Schematic representation of different mechanisms of HIF-1<i>α</i> activation. The picture shows a schematic representation of (a) HIF-1<i>α</i> degradation by proteasome under normoxic conditions, (b) HIF-1<i>α</i> stabilization under hypoxic conditions mediated by the oxygen deprivation which causes the inhibition of PHD2 activity, and (c) chemical-induced HIF-1<i>α</i> stabilization under normoxic conditions by the inhibition of PHD2 activity through DMOG treatment.</div>

Stem Cells International

fig1

Figure 1

Figure 1: Chemical Activation of the Hypoxia-Inducible Factor Reversibly Reduces Tendon Stem Cell Proliferation, Inhibits Their Differentiation, and Maintains Cell Undifferentiation 

Figure 1 | Chemical Activation of the Hypoxia-Inducible Factor Reversibly Reduces Tendon Stem Cell Proliferation, Inhibits Their Differentiation, and Maintains Cell Undifferentiation 