Human Bone Marrow Mesenchymal Stem Cells Promote Gastric Cancer Growth via Regulating c-Myc

Figure 1

hBM-MSC-CM increased c-Myc expression in gastric cancer cells. (a) c-Myc protein levels in MGC-803, BGC-823, and GES-1 were detected by Western blot analysis. , . (b) c-Myc levels after 48 h hBM-MSC-CM treatment. , (c) c-Myc protein levels maintained after withdrawal of hBM-MSC-CM treatment were detected by Western blot analysis. (d) MGC-803 cells were treated with 0.4 and 0.8 μM JQ1 for 24, 48, and 72 h. . (e, f) Compared with hBM-MSC-CM, hBM-MSC-CM + JQ1 decreased c-Myc expression in MGC-803 or BGC-823 cells. , .

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