Human Bone Marrow Mesenchymal Stem Cells Promote Gastric Cancer Growth via Regulating c-Myc

Figure 5

hBM-MSC-CM increased in vivo gastric tumor growth by upregulating c-Myc expression. (a) Tumor volumes of MGC-803 xenografts in immunocompromised mice. Tumor volumes of the JQ1 and hBM-MSC-CM + JQ1 groups were reduced compared with those of the hBM-MSC-CM and control groups; by Kruskal–Wallis test. (b, c) Comparison of tumor weights in each group at day 30; by Kruskal–Wallis test. (d) Expression of c-Myc in MGC-803 xenograft tissues of the different treatment groups was also detected with Western blot.

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