Stem Cells International / 2018 / Article / Tab 1

Review Article

Adjunctive Platelet-Rich Plasma (PRP) in Infrabony Regenerative Treatment: A Systematic Review and RCT’s Meta-Analysis

Table 1

Included studies.

StudyDesignStudy locationPopulation mean ageM/F ratioInterventionOutcomesFollow-upFlap placement

[19]RCT BADepartment of Periodontology, Semmelweis University, Budapest32–56 years13 M/11 FEMD + NBM + PRP versus EMD + NBMRegenerative surgery of deep infrabony defects12 months, 5 yearsCoronal advancement
[18]RCT SMUniversity of Dammam, College of Dentistry, Kingdom of Saudi Arabia41.4 ± 2.61 years7 M/5 FPRP + torus mandibularis chips versus torus mandibularis chipsTreatment for periodontal infrabony defects6 monthsOriginal
[20]RCTDepartment of Periodontics, Government Dental College and Research Institute, Bangalore, India36.8 yearsNAPRP versus OFDTreatment for periodontal infrabony defects9 monthsCoronal advancement
[21]RCTDepartment of Periodontology, Faculty of Dentistry, Gazi University, Ankara, Turkey48.96 ± 6.6 years9 M/5 FB-TCP + PRP versus B-TCPTherapeutic efficacy of platelet-rich plasma in infrabony defects6 monthsOriginal
[22]RCT SMDepartment of Periodontia, Saveetha Dental College and Hospitals Chennai20 and 50 yearsNAPRP + HA + B-TCP versus HA + TCPClinical effectiveness of regenerative techniques6 monthsOriginal
[23]RCT BADepartment of Periodontology, Semmelweis University, Budapest, Hungary28 to 65 years9 M/21 FPRP + ABBM versus ABBMModality to enhance the outcome of regenerative surgery12 monthsCoronal advancement
[24]RCT SMSchool of Dentistry, University of Belgrade, Republic of Serbia47 ± 10 years9 M/14 FBPBM + GTR + PRP versus BPBM + GTRAdditional benefits provided by the incorporation of platelet-rich plasma (PRP) into a regenerative protocol6 monthsOriginal
[25]RCTDivision of Periodontology, Polytechnic University of Marche, Ancona Torrette, Italy47 to 72 years31 M/29 FDFDBA + PRP versus DFDBACompare PRP combined with DFDBA to DFDBA in the treatment of human intrabony defects12 monthsCoronal advancement
[26]RCT BADepartment of Periodontology, Semmelweis University, Budapest, Hungary28 to 58 years12 M/16 FPRP + B-TCP + GTR versus B-TCP + GTRTo enhance the outcome of regenerative surgery12 monthsCoronal advancement
[27]RCTDepartment of Periodontology, Semmelweis University, Budapest, Hungary32–56 years12 M/14 FEMD + NBM + PRP versus EMD + NBMTo enhance the outcomes of regenerative surgery significantly12 monthsCoronal advancement
[28]RCT BADepartment of Periodontology, Semmelweis University, Budapest, Hungary26 to 55 years10 M/14 FPRP + ABBM + GTR or ABBM + GTRTo clinically evaluate the effect of PRP on the healing of deep intrabony defects12 monthsCoronal advancement
[29]RCTDivision of Periodontology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan55.5 ± 8.2 years21 M/49 FPRP + HA versus HA + salineTo compare platelet-rich plasma (PRP) combined with a biodegradable ceramic in the treatment of human intrabony defects12 monthsOriginal
[30]RCT SMSchool of Dentistry, University of California, Los Angeles41 ± 13 years16 M/12 FBPBM + GTR + PRP versus OFDClinical effectiveness of a combination therapy in the regeneration of periodontal intrabony defects in humans6 monthsOriginal
[31]RCT SMPrivate practice, Houston and Department of Periodontics, The University of Texas Health Science Center at Houston, TX37 to 74 years5 M/8 FPRP + BDX versus BDXThe combination of PRP and BDX to those obtained from the use of the bone replacement graft alone6 monthsCoronal advancement
[32]RCT SMClinical Specialties, Section of Periodontics, UCLA School of Dentistry, Los Angeles, CA, USA39 ± 9 years8 M/10 FPRP + BPBM + GTR versus GTRCombination therapy in promoting clinical signs of periodontal regeneration in intrabony defects6 monthsOriginal

EMD: enamel matrix derivative; NBM: natural bone mineral; PRP: platelet-rich plasma; OFD: open flap debridement; B-TCP: beta-tricalcium phosphate; ABBM: anorganic bovine bone mineral; BPBM: bovine porous bone mineral; GTR: guided tissue regeneration; DFDBA: demineralized freeze-dried bone allograft; BDX: bovine-derived xenograft.

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