Adjunctive Platelet-Rich Plasma (PRP) in Infrabony Regenerative Treatment: A Systematic Review and RCT’s Meta-Analysis

Table 1

Included studies.

Study	Design	Study location	Population mean age	M/F ratio	Intervention	Outcomes	Follow-up	Flap placement
[19]	RCT BA	Department of Periodontology, Semmelweis University, Budapest	32–56 years	13 M/11 F	EMD + NBM + PRP versus EMD + NBM	Regenerative surgery of deep infrabony defects	12 months, 5 years	Coronal advancement
[18]	RCT SM	University of Dammam, College of Dentistry, Kingdom of Saudi Arabia	41.4 ± 2.61 years	7 M/5 F	PRP + torus mandibularis chips versus torus mandibularis chips	Treatment for periodontal infrabony defects	6 months	Original
[20]	RCT	Department of Periodontics, Government Dental College and Research Institute, Bangalore, India	36.8 years	NA	PRP versus OFD	Treatment for periodontal infrabony defects	9 months	Coronal advancement
[21]	RCT	Department of Periodontology, Faculty of Dentistry, Gazi University, Ankara, Turkey	48.96 ± 6.6 years	9 M/5 F	B-TCP + PRP versus B-TCP	Therapeutic efficacy of platelet-rich plasma in infrabony defects	6 months	Original
[22]	RCT SM	Department of Periodontia, Saveetha Dental College and Hospitals Chennai	20 and 50 years	NA	PRP + HA + B-TCP versus HA + TCP	Clinical effectiveness of regenerative techniques	6 months	Original
[23]	RCT BA	Department of Periodontology, Semmelweis University, Budapest, Hungary	28 to 65 years	9 M/21 F	PRP + ABBM versus ABBM	Modality to enhance the outcome of regenerative surgery	12 months	Coronal advancement
[24]	RCT SM	School of Dentistry, University of Belgrade, Republic of Serbia	47 ± 10 years	9 M/14 F	BPBM + GTR + PRP versus BPBM + GTR	Additional benefits provided by the incorporation of platelet-rich plasma (PRP) into a regenerative protocol	6 months	Original
[25]	RCT	Division of Periodontology, Polytechnic University of Marche, Ancona Torrette, Italy	47 to 72 years	31 M/29 F	DFDBA + PRP versus DFDBA	Compare PRP combined with DFDBA to DFDBA in the treatment of human intrabony defects	12 months	Coronal advancement
[26]	RCT BA	Department of Periodontology, Semmelweis University, Budapest, Hungary	28 to 58 years	12 M/16 F	PRP + B-TCP + GTR versus B-TCP + GTR	To enhance the outcome of regenerative surgery	12 months	Coronal advancement
[27]	RCT	Department of Periodontology, Semmelweis University, Budapest, Hungary	32–56 years	12 M/14 F	EMD + NBM + PRP versus EMD + NBM	To enhance the outcomes of regenerative surgery significantly	12 months	Coronal advancement
[28]	RCT BA	Department of Periodontology, Semmelweis University, Budapest, Hungary	26 to 55 years	10 M/14 F	PRP + ABBM + GTR or ABBM + GTR	To clinically evaluate the effect of PRP on the healing of deep intrabony defects	12 months	Coronal advancement
[29]	RCT	Division of Periodontology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan	55.5 ± 8.2 years	21 M/49 F	PRP + HA versus HA + saline	To compare platelet-rich plasma (PRP) combined with a biodegradable ceramic in the treatment of human intrabony defects	12 months	Original
[30]	RCT SM	School of Dentistry, University of California, Los Angeles	41 ± 13 years	16 M/12 F	BPBM + GTR + PRP versus OFD	Clinical effectiveness of a combination therapy in the regeneration of periodontal intrabony defects in humans	6 months	Original
[31]	RCT SM	Private practice, Houston and Department of Periodontics, The University of Texas Health Science Center at Houston, TX	37 to 74 years	5 M/8 F	PRP + BDX versus BDX	The combination of PRP and BDX to those obtained from the use of the bone replacement graft alone	6 months	Coronal advancement
[32]	RCT SM	Clinical Specialties, Section of Periodontics, UCLA School of Dentistry, Los Angeles, CA, USA	39 ± 9 years	8 M/10 F	PRP + BPBM + GTR versus GTR	Combination therapy in promoting clinical signs of periodontal regeneration in intrabony defects	6 months	Original

EMD: enamel matrix derivative; NBM: natural bone mineral; PRP: platelet-rich plasma; OFD: open flap debridement; B-TCP: beta-tricalcium phosphate; ABBM: anorganic bovine bone mineral; BPBM: bovine porous bone mineral; GTR: guided tissue regeneration; DFDBA: demineralized freeze-dried bone allograft; BDX: bovine-derived xenograft.