Zebularine Promotes Hepatic Differentiation of Rabbit Bone Marrow Mesenchymal Stem Cells by Interfering with p38 MAPK Signaling

Figure 5

Recruitment of ALB in the cytoplasm of BMMSCs on the 21st day. (a) Noninduced BMMSCs, (b) HGF, (c) HGF + SB203580, (d) HGF + zebularine, (e) HGF + zebularine + SB203580, and (f) primary rabbit hepatocytes. Cells analyzed by immunofluorescence with ALB (green) as a hepatocyte marker and DAPI to stain nuclear (blue). There were (18.67 ± 6.19)%, (26.71 ± 7.31)%, (70.04 ± 6.09)%, (71.82 ± 5.67)%, and (89.36 ± 5.38)% positive cells in HGF, HGF + SB203580, HGF + zebularine, HGF + zebularine + SB203580, and primary rabbit hepatocyte groups, respectively.

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