Bone Morphogenetic Protein 6 Inhibits the Immunomodulatory Property of BMMSCs via Id1 in Sjögren’s Syndrome

Figure 4

Knockdown of Id1 rescued impaired immunosuppressive capacity of BMMSCs induced by BMP6 in vivo. (a, b) BMMSCs treatment significantly reduced the number of CD4⁺ T cells, while BMP6-treated BMMSCs showed no significant reduction. When Id1 was blocked by siRNA in BMP6-treated BMMSCs, a greater reduction in CD4⁺ T cells number was observed (, ). (c, d) A greater ratio of Th1 cells were detected in the presence of BMP6 compared with BMMSCs alone. Knockdown of Id1 significantly decreased the proportion of Th1 cells. ().

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