Insights into Endothelial Progenitor Cells: Origin, Classification, Potentials, and Prospects

Table 3

Current status of clinical trials investigating EPCs and its relation to a single factor in disorders or diseases.

	Completed (90)	Recruiting (37)	Active, but not recruiting (13)	Not yet recruiting (8)	Terminated (14)	Withdrawn (10)	Unknown status (38)	NA (0)	Enrolled by invitation (1)
Disorder of CVS	47	15	7	1	8	5	15	0
	e.g., MI, angina, hypertension, peripheral vascular disease (PVD), arteriosclerosis, coronary artery ischaemia	e.g., MI, cardiomyopathy, coronary artery disease (CAD), PVD, critical limb ischaemia (CLI), atherosclerosis	e.g., CAD, CLI, atherosclerosis	CLI	e.g., angina, CAD	e.g., ischaemic congestive heart failure (CHF), lower limb ischaemia	e.g., aortic aneurysm, CHF, CAD, PVD
Renal disease	2	1
	End-stage renal disease and chronic kidney disease	Acute kidney injury
GIT disorders	3	2					1
	Liver cirrhosis, nonalcoholic fatty liver disease, and severe hepatic venoocclusive disease	End-stage liver disease and sinusoidal obstruction syndrome					Crohn’s disease
Endocrine disorders	13	4	2	2		2	5
	e.g., type 1 and type II DM	e.g., type II DM	e.g., type II DM etc.	e.g., type II DM etc.		e.g., type II DM	e.g., type 1 and type II DM
Neoplastic disorders	3	2			4		5
	e.g., breast cancer, colorectal cancer, and nonsmall cell lung cancer	e.g., BRCA1, BRCA2 gene mutation, cervical cancer			e.g., renal cell carcinoma, multiple myeloma		e.g., breast cancer, lung cancer
Healthy subjects	7	1	1	1			1
	e.g., healthy subjects	Obesity	Healthy	Quality of life			Morbid obesity
Respiratory disease	2	1		1			3
	Idiopathic pulmonary arterial hypertension	Pulmonary emphysema		Pulmonary hypertension			e.g., chronic obstructive pulmonary disease (COPD), idiopathic pulmonary arterial hypertension
Reproductive disorders	3				1
	e.g., polycystic ovary syndrome (PCOS)				e.g., PCOS
Musculoskeletal disorders	1		1
	Ankylosing spondylitis		Bone defects
Neurologic diseases	2	4	1			2	2		1
	Central nervous system and acute ischaemic stroke	Stroke, aneurysmal subarachnoid haemorrhage, and mild cognitive impairment	Brain and central nervous system tumours			Traumatic brain injury	Ischaemic stroke and migraine with aura		Diabetic foot ulcer
Hematological disorders	4	5		2	1	1	4
	Endotoxemia, sickle cell anaemia, dyslipidemia, and hypoxia	Sickle cell disease without crisis, hypercholesterolemia, microgravity-exposed endothelial cells, hemolytic uremic syndrome, and soft-tissue sarcoma		Dystrophic epidermolysis bullosa and septic shock	Graft-versus-host disease	Sickle cell anaemia	Exercise anaphylaxis, recurrent adult Hodgkin lymphoma, acute myeloid leukemia, and brachial plexus (pressure)
Autoimmune disorders		1					1
		Systemic scleroderma					Systemic lupus erythematosus
Dental disorders				1
				Tooth impacted
Miscellaneous	3	1	1				1
	Burn, bullous keratopathy, ischaemic ulcer	Sepsis	Delayed graft function				SDF-1