Ex Vivo Expansion of Murine MSC Impairs Transcription Factor-Induced Differentiation into Pancreatic β-Cells

Figure 5

Transplantation of MSC-INS-FUR in STZ-diabetic NOD/Scid mice. (a) Blood glucose concentrations of treated STZ-diabetic NOD/Scid mice. Blood glucose measurements were recorded daily post-STZ injection for the duration of the experiment (36 days). Data were presented as means ± SEMs ( mice per group). Two-way ANOVA with Sidak’s posttests were performed, . (b) Body weights of treated STZ-NOD/Scid mice. Body weight measurements were recorded daily post-STZ injection for the duration of the experiment (36 days). Data were presented as means ± SEMs ( mice per group). Two-way ANOVA was performed with Sidak’s posttests, . (c) IPGTT in treated STZ-diabetic NOD/Scid mice. Blood glucose measurements were obtained at 0, 5, 15, 30, 60, and 90 min post-D-Glucose injection. Data were presented as means ± SEMs (, normal; , treated). Two-way ANOVA with Sidak’s posttests were performed, .

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