Luteolin-7-glucoside Promotes Human Epidermal Stem Cell Proliferation by Upregulating β-Catenin, c-Myc, and Cyclin Expression

Figure 4

Luteolin-7-glucoside promotes EpSC proliferation through upregulating β-catenin, c-Myc, and cyclins. (a, b) Human EpSCs were treated with or without 1 μM luteolin-7-glucoside (L7G) for different periods of time (a) or 24 h (b) and examined for the expression of β-catenin, c-Myc, and cyclins by RT-PCR (a) and Western blot (b), respectively. Images are representative results of 3 independent experiments. (c) Human EpSCs were treated with 1 μM L7G combined with 2 μM XAV-939 or 10058-F4 for 48 h. Data are shown as (). , compared with untreated cells. and , compared with cells treated with L7G alone.

(a)

(b)

(c)