Bioinformatic Analysis of Transcriptomic Data Reveals Novel Key Genes Regulating Osteogenic Differentiation of Human Adipose Stem Cells

Figure 6

The inhibition of C5AR1 suppressed the osteogenic differentiation of ASCs. (a) The expression of C5AR1 mRNA and protein was significantly increased during osteogenic differentiation of ASCs. (b) The expression level of C5AR1 mRNA and protein was dramatically downregulated following siC5AR1 transfection. (c) C5AR1 downregulation inhibited the expression of osteogenic differentiation markers. (d) C5AR1 downregulation suppressed the calcium nodule formation capacity of ASCs.

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