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| Publication | Study design | Disease | Therapeutic protocol | Outcome | Patient characteristic | F-up | Main findings |
|
| Jones et al. [28] | RCT (NCT03242707) | OA | Comparative study: ultrasound-guided, intra-articular injection of autologous adipose tissue vs. HA | WOMAC, PROMIS questionnaire, synovial fluid analysis, sway velocity assessment | 54 (27 vs. 27)
Age: N/A
Sex: M-F: N/A
K-L: N/A | 6 months | Ongoing. |
| Roato et al. [29] | Prospective | OA | Following diagnostic arthroscopy, 35 ml of concentrated adipose tissue was injected intra-articularly | WOMAC, VAS, MRI, immunohistochemistry of 2 knees | 20
Age: 59.6
Sex: M-F: 9-11
K-L: I-III | 18 months | Whilst both WOMAC and VAS scores improved significantly, WOMAC scores showed progressively better outcomes. MRI Outerbridge grade did not show significant changes. Immunohistochemistry displayed new tissue growth. |
| Hong et al. [33] | Double-blind RCT (HA in contralateral knee) | Bilateral OA | Comparative study: arthroscopic debridement followed by intra-articular SVF injection vs. HA injection in the contralateral knee | VAS, WOMAC, ROM, whole-organ MRI score, MRI observation of cartilage repair tissue | 16 (32 knees): (16 vs. 16)
Age: 18-70 years
Sex: M-F:
K-L: II-III | 12 months | VAS and WOMAC scores and knee ROM improved significantly for both groups, but these improvements were not long lasting in the control group. MRI analysis showed significantly increased cartilage repair in the SVF group compared to the control. |
| Hudetz et al. [26] | Prospective | OA | Microfragmented adipose tissue injection | VAS, radiographs, dGEMRIC MRI, IgG isolation from plasma and synovial fluid | 17 (32 knees)
Age: 40-85
Sex: M-F: 12-5
K-L: III-IV | 12 months | Significant decrease in VAS scores. No change in IgG glycome composition. dGEMRIC MRI analysis displayed increase in proteoglycan content within the ECM. |
| Bansal et al. [30] | Prospective (phase I)
NCT03089762 | OA | SVF+PRP injection | WOMAC, 6-minute walking distance, MRI | 10 (13 knees)
Age: ≥50
Sex: N/A
K-L: I-II | 24 months | Significant improvement of WOMAC scores and 6-minute walking distance. MRI showed increase in cartilage thickness in all but 2 patients. All patients are satisfied with therapy. |
| Yokota et al. [27] | Prospective | OA | Intra-articular injection of SVF | VAS, WOMAC, Japanese Knee Osteoarthritis Measure (JKOM) | 13 (26 knees)
Age: 74.5
Sex: M-F: 2-11
K-L: III-IV | 6 months | All VAS, WOMAC, and JKOM scores improved significantly at the 6-month (last) follow-up. |
| Nguyen et al. [37] | Comparative prospective | OA | Comparative study: arthroscopic microfracture (AM) and SVF+PRP injection vs. AM alone | WOMAC, VAS, and Lysholm scores, MRI, knee joint function | 30 (15 vs. 15)
Age: 58.60 vs. 58.20
Sex: M-F: 3-12vs. 3-12
K-L: II-III | 18 months | WOMAC, Lysholm, and VAS scores improved for both groups up to 12 months, but at 18 months, the SVF group was significantly better than the control group. At 12 months, the SVF group displayed significantly less bone marrow edema than the control group. |
| Koh et al. [36] | Prospective | OA | Following arthroscopic lavage is intra-articular injection of SVF+PRP to the most severe cartilaginous defects | Lysholm, VAS, and KOOS scores, radiographs, 2nd-lookarthroscopy | 30
Age: ≥60
Sex: M-F: 5-25
K-L: II-III | 24 months | Lysholm, VAS, and KOOS scores all improved significantly. Scores increased at the second year compared to the first year of follow-up. Second-look arthroscopy determined the majority of knees as positive or better. |
| Kim et al. [34] | Prospective comparative | OA | Comparative study: following arthroscopic debridement, group 1 received an intra-articular injection of SVF; group 2 received an intra-articular injection of SVF+fibrin glue as a scaffold | IKDC, Tegner, 2nd-lookarthroscopic ICRS grading | 54 (56 knees): 37 vs. 17
Age: 57.5 vs. 57.7
Sex: M-F: 14-23vs. 8-9
K-L: I-II | 29.2 vs. 27.3 months | IKDC and Tegner activity scores significantly improved in both groups but showed no significant difference. Statistical significance between the two groups was observed in ICRS grades, with the SVF group being more positive. A higher BMI resulted in less positive outcomes. |
| Koh et al. [32] | Prospective comparative | OA | Comparative study: intra-articularinjection of SVF+PRP vs. only PRP prior to performing open-wedge high tibial osteotomy | Lysholm, KOOS, VAS, and femorotibial angle. Arthroscopic evaluation | 44 (23 vs. 21)
Age: 52.3 vs. 54.2
Sex: M-F: 6-17vs. 5-16
K-L: I-III | 24-25 months (mean: 24.4) | Lysholm, VAS score, and KOOS improved statistically in both groups. KOOS improvements were statistically greater in the SVF group. No difference in the preoperative and postoperative femorotibial angles. SVF group displayed greater fibrocartilage coverage. |
| Koh et al. [35] | Retrospective | OA | Arthroscopic debridement+administration of SVF to articular chondral lesions | IKDC score and Tegner activity scale, 2nd-look arthroscopic ICRS grading | 35 (37 knees)
Age: 48-69
Sex: M-F: 14-21
K-L: I-II | 24-34 months (mean: 26.5) | IKDC and Tegner activity scores significantly improved. Patients reported high satisfaction scores. It was noted that a higher BMI resulted in less positive outcomes. |
| Bui et al. [31] | Prospective | OA | Intra-articular SVF+PRP injection | VAS and Lysholm scores, MRI | 21
Age: ≤18
Sex: N/A
K-L: II-II | 6 months | Statistically significant improvement in VAS and Lysholm scores. MRI analysis showed partial regeneration and thickening of articular cartilage. |
| Koh et al. [38] | Retrospective | OA | Infrapatellar SVF+PRP, intra-articularinjection+weekly PRP injection for 2 weeks | Whole-organ MRI, WOMAC, VAS, and Lysholm scores | 18
Age: 41-69
Sex: M-F: 6-12
K-L: III-IV | 24-26 months (mean: 24.3) | Significant decrease of WOMAC, VAS, and Lysholm scores. Significant decrease of whole-organ MRI scores. Extent of improvement was directly correlated with the amount of MSCs injected. |
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