Minimally Manipulated Mesenchymal Stem Cells for the Treatment of Knee Osteoarthritis: A Systematic Review of Clinical Evidence

Table 3

BMAC study quality assessment with the Coleman methodology score modified by Kon et al.

	Study	TOT	Study size	Mean f-up	Different surg proc	Type of study	Surg proc description	Postop rehab	MRI outcome	Histological outcome	Outcome criteria	Outcome assessment	Selection process
Bone marrow aspirate concentrate	Hernigou et al. [25]	70	7	10	10	15	5	5	10	0	5	3	0
	Themistocleous et al. [16]	44	10	0	10	0	5	5	0	0	5	3	6
	Shaw et al. [17]	23	0	0	10	0	5	0	0	0	5	3	0
	Rodriguez-Fontan et al. [18]	30	0	2	10	0	5	2	0	0	5	3	3
	Shapiro et al. [19]	51	7	2	4	15	5	0	10	0	2	3	3
	Sampson et al. [20]	26	10	0	4	0	5	2	0	0	2	0	3
	Vad et al. [24]	49	0	2	10	10	5	0	10	0	5	7	0
	Centeno et al. [21]	26	10	0	4	0	5	2	0	0	2	3	0
	Centeno et al. [22]	23	10	0	4	0	5	2	0	0	2	0	0
	Kim et al. [23]	32	10	0	4	0	5	5	0	0	5	3	0