Mechanical Stretch Promotes the Osteogenic Differentiation of Bone Mesenchymal Stem Cells Induced by Erythropoietin

Figure 6

The levels of p-ERK1/2 under mechanical stretch combined with 20 IU/ml EPO. The p-ERK1/2 expression of the cells subjected to mechanical stretch with or without EPO was more obvious than the control. The group subjected to mechanical stretch combined with 20 IU/ml EPO yielded the largest effect relative to the control (a, b). Furthermore, the U0126, an inhibitor of ERK1/2, inhibited the ALP activity induced by mechanical stretch combined with 20 IU/ml EPO (c). and compared with the control group.

(a)

(b)

(c)