Cend1, a Story with Many Tales: From Regulation of Cell Cycle Progression/Exit of Neural Stem Cells to Brain Structure and Function

Figure 4

Cend1-associated pathways during cerebellar development. Cend1 negatively regulates proliferation of granule cell precursors (GCPs) via inhibition of Shh/Cyclin D1. In addition, Cend1 promotes BDNF secretion which induces Reelin-dependent GC migration and Purkinje cell differentiation.