The Manufacture of GMP-Grade Bone Marrow Stromal Cells with Validated In Vivo Bone-Forming Potential in an Orthopedic Clinical Center in Brazil

Table 3

Number of population doublings and the doubling time for each BMSC passage.

	Population doubling				Time for population doubling (days)
	P0	P1	P2	Cpd		P0	P1	P2
BMSC 05	9.75	4.07	3.30	17.12		1.43	1.47	2.12
BMSC 06	3.23	3.58	2.22	9.04		4.33	0.84	2.70
BMSC 07	12.31	4.13	1.50	17.94		1.13	0.73	3.99
BMSC 08	12.05	2.26	2.00	16.31		1.16	1.77	2.50
BMSC 09	11.85	3.43	5.06	20.34		1.18	2.04	1.38
BMSC 10	11.02	2.26	1.50	15.51		1.26	3.09	4.66
BMSC 11	11.74	2.28	2.58	16.60		1.19	3.08	2.71
BMSC 12	11.99	2.58	0.74	15.31		1.16	2.71	9.50
BMSC 13	12.08	2.32	2.00	16.04		1.15	3.01	3.50
BMSC 14	11.37	2.38	1.99	15.74		1.23	2.94	3.52
					Median	1.18	2.37	3.10

Cpd: cumulative population doubling. vs. P0; Kruskal Wallis with Dunn’s multiple comparisons test.