The Genetic Landscape of Human Glioblastoma and Matched Primary Cancer Stem Cells Reveals Intratumour Similarity and Intertumour Heterogeneity

Figure 2

Genome view of GBM and GSCs of each patient displaying high intrapatient similarity and interpatient discordance. Gains or losses of chromosomal regions are computed by comparing signal intensity in GBM and GSCs with the background signal of the reference and then applying a segmenting and smoothing algorithm. Line plots show chromosomal changes seen in GBMs; the -axis indicates the log2 value ranging from -5 to 5; blue indicates gain/amplifications, red losses/deletions.