Identification of Aberrantly Expressed Genes during Aging in Rat Nucleus Pulposus Cells

Table 4

List of top 5 terms of upregulated genes enriched by GO and KEGG analysis.

Terms	Count	-log10 ( value)
KEGG:rno04668:TNFsignaling pathway	15	4.863619311
KEGG:rno04151:PI3K-Aktsignaling pathway	27	4.249211392
KEGG:rno05200:Pathways in cancer	29	3.912805981
KEGG:rno04630:Jak-STAT signaling pathway	14	3.272521081
KEGG:rno04512:ECM-receptor interaction	10	2.566175661
GO BP:0032496~response to lipopolysaccharide	29	7.485884419
GO BP:0014070~response to organic cyclic compound	28	7.172760304
GO BP:0008285~negative regulation of cell proliferation	33	6.863888026
GO BP:0001666~response to hypoxia	27	6.668325051
GO BP:0050680~negative regulation of epithelial cell proliferation	13	5.878814283
GO MF:0004866~endopeptidase inhibitor activity	9	5.741812795
GO MF:0001077~transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding	24	5.695518301
GO MF:0005509~calcium ion binding	39	3.672674033
GO MF:0008134~transcription factor binding	23	3.591418924
GO MF:0043565~sequence-specific DNA binding	33	3.418128712
GO CC:0005615~extracellular space	99	16.94638876
GO CC:0070062~extracellular exosome	135	9.756235253
GO CC:0009986~cell surface	48	8.51199254
GO CC:0005578~proteinaceous extracellular matrix	25	6.200499673
GO CC:0031012~extracellular matrix	25	6.169491531