Identification of Aberrantly Expressed Genes during Aging in Rat Nucleus Pulposus Cells

Table 7

The hub genes were analysed by different topological algorithms in the protein-protein interaction network.

Topological algorithm	Top 20 genes were ranked by score
Maximal Clique Centrality (MCC)	Btg2, Clu, Csf1, Cx3cl1, Cxcl1, Cxcl5, Dusp1, Egr1, Egr2, Fos, Ier2, Igf1, Junb, Kng1, Kng2, Nfkbiz, Penk, Ptgs2, Serping1, Zfp36
Degree	A2m, Acta2, Clu, Col3a1, Csf1, Cxcl1, Cxcl5, Dusp1, Egr1, Fos, Igf1, Il7, Kitl, Kng1, Kng2, Postn, Ptgs2, Socs3, Vcam1, Vcan
Edge Percolated Component	Cd68, Clu, Cp, Csf1, Cx3cl1, Cxcl1, Cxcl5, Egr1, Fos, Igf1, Il7, Kitl, Kng1, Kng2, Nfkbiz, Penk, Ptgs2, Serpina3n, Socs3, Vcam1
Maximum Neighborhood Component	Acta2, Clu, Col3a1, Csf1, Cx3cl1, Cxcl1, Cxcl5, Dusp1, Egr1, Fos, Igf1, Il7, Kitl, Kng1, Kng2, Nfkbiz, Postn, Ptgs2, Serpina3n, Vcam1
BottleNeck	A2m, Acta1, Cd68, Cfh, Cxcl1, Dusp1, Egr1, Eng, Folr2, Fos, Igf1, Il7, Jag1, Kitl, Mcam, Negr1, Postn, Ptgs2, Timp3, Vcam1
EcCentricity	Acta2, Cd68, Csf1, Cx3cl1, Cxcl1, Egr1, Eng, Fgf10, Fgf9, Fgfr2, Fos, Igf1, Junb, Lyz2, Mmp12, Myh11, Ptgs2, Serping1, Smad9, Vcam1
Common genes of 6 topological algorithms	Cxcl1, Egr1, Fos, Igf1, Ptgs2