Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells

Figure 4

Inhibition of tissue development functional category and NOTCH-associated signaling networks in LY411575-treated hBMSCs. (a) Disease and function heat map depicting activation (red) or inhibition (blue) of the indicated functional and disease categories identified in the differentially expressed transcripts in LY411575-treated hBMSCs. (b, c) Heat map-illustrating affected tissue development functional category and associated functional annotations, respectively. Illustration of the TGFβ1 (d), SPP1 (e), and ERK (f) genetic networks with predicted activated state of the network based on transcriptome data and with subsequent predicted effects on downstream effector molecules. Figure legend illustrates the relationship between molecules within the network.

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