Mesenchymal Stem Cells Exhibit Both a Proinflammatory and Anti-Inflammatory Effect on Saccular Aneurysm Formation in a Rabbit Model

Figure 3

(a) Elastin semiquantification of the tunica media in the control and experimental group aneurysms. No significant difference in elastin content was found (, , ). Box and whisker plots demonstrate median, quartiles and maximum/minimum values (withholding outlier, represented by an open circle). (b) Tunica media thickness and (c) tunica intima hyperplasia (when present) measured histologically in the control and treatment group aneurysms. Tunica media thickness was normalized to parent vessel thickness. No significant differences were seen in tunica media thickness (, , ), but the control group demonstrated significantly more tunica intima hyperplasia than the treatment group (, , ).

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