Meta-Analysis and Evidence Base for the Efficacy of Autologous Bone Marrow Mesenchymal Stem Cells in Knee Cartilage Repair: Methodological Guidelines and Quality Assessment

Table 4

Mean Coleman methodology score of the studies according to the level of evidence, type of therapy, and cell preparation.

	No. of studies	Mean Coleman methodology score (range)
Level of evidence
I	4	66.25 (54-77)
II	5	62 (54-75)
III	2	68.5 (68-69)
IV	21	49 (32-63)
Type of therapy
Intra-articular injection	9	52.2 (36-77)
One step	14	55.4 (32-68)
Surgical delivery	9	55.1 (37-75)
Cell culture
Cultured	17	53.6 (36-77)
Noncultured	14	55.4 (32-68)
Cellular centrifugation
BMAC	18	55.2 (35-69)
BMA	13	53.3 (32-77)