Complementary Embryonic and Adult Cell Populations Enhance Myocardial Repair in Rat Myocardial Injury Model

Figure 4

Combination of Isl-1⁺cells and CD90⁺ cells leads to improved cardiac function, and schematic representation of combination stem cell administration on cardiac repair following LAD ligation induced MI. (a) Representative screenshots of echocardiograms at 1- and 4-week post-MI time points in all the four treatment groups (saline, Isl-1⁺, CD90⁺, and Isl-1⁺/CD90⁺). (b) Hemodynamic parameter assessment by Millar catheterization revealed that the combination therapy group demonstrated a significant improvement of cardiac function compared to either monotherapy. There was no significant difference between Isl-1⁺/CD90⁺ and sham. (c) Isl-1⁺ cells derived from mouse embryos and adult bone marrow-derived CD-90⁺ cells work in combination to restore cardiac function and preserve wall thickness in the LAD ligation model of MI. In vivo cells work in synergy to carry out healing and the use of two cell types may serve to optimize outcomes both for the target tissue in need of repair and for facilitating donor cell survival.

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