Mitochondrial Role in Stemness and Differentiation of Hematopoietic Stem Cells

Figure 2

Effect of different levels of p53 in HSCs. Adequate p53 level and activity regulate the quiescent and self-renewing potential of HSCs by reducing ROS levels (boxed area). Lack of p53 impairs the quiescent state and self-renewing potential of HSCs and compromises the functional fitness of HSCs. Decreased p53 expression levels and activity promote differentiation of HSCs. Upon high levels of oxidative stress and ROS, increased p53 activity leads to senescence or cell death.