Geranylgeraniol (GGOH) as a Mevalonate Pathway Activator in the Rescue of Bone Cells Treated with Zoledronic Acid: An In Vitro Study

Figure 1

WST-1 activity of bone cells (OBs and OCs). Effect of ZA (0.1, 25, and 100 μM) and GGOH (10, 20, 40, and 80 μM) on the cell activity of bone cells. The cell proliferation was measured by WST-1 assay. (a) Human osteoblasts and (b) human osteoclasts were treated with different concentrations of ZA and GGOH for 7 days. The results are presented as the mean and standard deviation of the percentage of cell viability to the positive controls (). The results represent absorbance values measured at 450 nm against the background control wells using 650 nm as a reference. ANOVA tests and Bonferroni corrections for multiple comparisons were applied. Significant difference between controls and test groups: , , , and .

(a)

(b)