Geranylgeraniol (GGOH) as a Mevalonate Pathway Activator in the Rescue of Bone Cells Treated with Zoledronic Acid: An In Vitro Study

<div>TRAP staining assay of osteoclast. Osteoclasts were cultured at different concentrations of ZA (0.1, 25, and 100 <i>μ</i>M) and GGOH (10, 20, 40, and 80 <i>μ</i>M) for 7 days. Magnification: ×10, scale bar: 200 <i>μ</i>m. TRAP staining of human osteoclasts differentiated in vitro on polystyrene flasks. Representative images are depicted from two different cell lots.</div>

Stem Cells International

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Figure 3: Geranylgeraniol (GGOH) as a Mevalonate Pathway Activator in the Rescue of Bone Cells Treated with Zoledronic Acid: An In Vitro Study 