Macrophages Are Key Regulators of Stem Cells during Skeletal Muscle Regeneration and Diseases

Figure 2

Macrophage-centered therapeutic approaches. Different strategies were developed to restore a balance in macrophage polarization in chronic degenerative muscle disorders. These strategies include cytokines (e.g., IL-10), nutritional compounds (e.g., PUFA and vitamins), RNA silencing (e.g., miRNA), pharmacological drugs (e.g., glucocorticoids), and biomaterials (synthetic, biological, or mixed). These strategies could be used to skew macrophage polarization toward their pro- or anti-inflammatory phenotype depending on the desired therapeutic effect.