Rat Hippocampal Neural Stem Cell Modulation Using PDGF, VEGF, PDGF/VEGF, and BDNF

Figure 1

(a) Hippocampal neural stem cell counts per field of view in each growth factor treatment. Graph showing the number of cells per field of view for each growth factor treatment group at 20 ng/mL and 100 ng/mL vs. positive and negative controls after 14 days of treatment. Significantly different from DMEM (); ^xsignificantly different from all treatments except for DMEM (); ^{^}different from all treatments (). PDGF: platelet-derived growth factor; VEGF: vascular endothelial growth factor; BDNF: brain-derived neurotrophic factor; DMEM: Dulbecco’s modified Eagle’s medium. (b) % confluence of cells at day 0 vs. day 14. Graph showing cell confluence at day 0 vs. day 14 for each treatment group at 20 ng/mL and 100 mL and controls. Cell confluence significantly reduced after 14-day treatment in all treatments except in PDGF (100 ng/mL) and PDGF/VEGF (100 ng/mL); . (c) Absorbance values at 570 nm for the resazurin redox stress assay at day 14 for each treatment.

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