Adipose Tissue-Derived Stem Cells Have the Ability to Differentiate into Alveolar Epithelial Cells and Ameliorate Lung Injury Caused by Elastase-Induced Emphysema in Mice

Figure 5

Functional effects of the administration of ADSCs in emphysema model mice. (a) A pulmonary function test was performed in mice in the following four groups: control, administered 50 μl PBS intratracheally; PPE+/ADSCs−, administered PPE intratracheally; PPE−/ADSCs+, administered 50 μl PBS intratracheally and injected with ADSCs intravenously; and PPE+/ADSCs+, administered PPE intratracheally and injected with ADSCs intravenously. Lung compliance indicated as C chord and vital capacity were measured by the lung function analysis system ( in the control group, in the PPE+/ADSC− group, in the PPE−/ADSC+ group, and in the PPE+/ADSC+ group on each day). . (b) Representative hyperpolarized ¹²⁹Xe magnetic resonance imaging (MRI). A representative map of the gas exchange efficiency () and the ventilation efficiency () is shown. The values of and ra were measured ( in the control group, in the PPE+/ADSC− group, in the PPE−/ADSC+ group, and in the PPE+/ADSC+ group). .

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