Stem Cells International / 2019 / Article / Fig 1

Research Article

The Analysis of In Vivo Aging in Human Bone Marrow Mesenchymal Stromal Cells Using Colony-Forming Unit-Fibroblast Assay and the CD45lowCD271+ Phenotype

Figure 1

Age-related decline in number and proliferative capacity of BM MSCs. (a) Correlation between CFU-Fs/ml of BM aspirate with donor age across complete age range (left, donors, 19-89 years old) and between three age groups (right); black lines indicate the line of the best fit (left) and median values for each group (right). (b) Representative colony dish showing the presence of large and small colonies (left) and comparison of colony areas in all colonies in 7 young donors (19-37 years old, 321 colonies) and 7 old donors (61-76 years old, 266 colonies) (right). Each dot represents a single colony; black lines represent median values. (c) Frequency distribution of colony areas for colonies from the same 7 young (black curve) and 7 old donors (grey curve) (left) and comparison of integrated densities (IDs) of smaller colonies (left) and larger colonies (right) in the young and old donor groups. , , , and .
(a)
(b)
(c)

We are committed to sharing findings related to COVID-19 as quickly and safely as possible. Any author submitting a COVID-19 paper should notify us at help@hindawi.com to ensure their research is fast-tracked and made available on a preprint server as soon as possible. We will be providing unlimited waivers of publication charges for accepted articles related to COVID-19. Sign up here as a reviewer to help fast-track new submissions.