Research Article
The Effect of Vascular Endothelial Growth Factor on Bone Marrow Mesenchymal Stem Cell Engraftment in Rat Fibrotic Liver upon Transplantation
Table 2
Laennec scoring system for staging fibrosis in liver biopsies.
| Stage | Name | Septa (thickness and number) | Criteria | Score |
| 0 | No definite fibrosis | | | 0 | 1 | Minimal fibrosis | +/− | No septa or rare thin septum; may have portal expansion or mild sinusoidal fibrosis | 1 | 2 | Mild fibrosis | + | Occasional thin septa; may have portal expansion or mild sinusoidal fibrosis | 2 | 3 | Moderate fibrosis | ++ | Moderate thin septa; up to incomplete cirrhosis | 3 | 4A | Cirrhosis, mild, definite, or probable | +++ | Marked septation with rounded contours or visible nodules. Most septa are thin (one broad septum allowed) | 4 | 4B | Moderate cirrhosis | ++++ | At least two broad septa, but no very broad septa and less than half of biopsy length composed of minute nodules | 5 | 4C | Severe cirrhosis | +++++ | At least very broad septum or more than half of biopsy length composed of minute nodules | 6 |
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