Oligodendroglial Lineage Cells in Thyroid Hormone-Deprived Conditions

Figure 2

The expression of MCT8 in human oligodendrocytes and its altered expression pattern in secondary progressive MS. Immunofluorescent images illustrating (a) the axonal and oligodendroglial expression of MCT8 in nonneurological disease control (NNDC) brain tissue. (b) Secondary progressive MS cerebellar white matter stained with Luxol fast blue with periodic acid Schiff (LFB/PAS) demonstrating chronic demyelinated lesions (light purple in the center) and with Bielschowsky silver stain demonstrating axonal loss and degeneration. Immunofluorescent images illustrating (c) apoptotic Olig2+ oligodendroglial lineage cells, and (d) apoptotic oligodendrocytes expressing MCT8 in secondary progressive multiple sclerosis cerebellar white matter (outlined in the box in (b)).

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