Mesenchymal Stem Cell-Derived Extracellular Vesicles for Corneal Wound Repair

<div>Enhanced therapeutic effect of EVs in the alkali burn model. (a) H&amp;E staining of the cornea demonstrated stromal edema and inflammatory cell infiltration on days 7 and 14 after injury in EV-treated mice, compared with the cornea without injury. The arrowheads pointed to the disorganized fibers and phlyctenule in the epithelium layer. The degree of repair of the epithelial layer in the control group was significantly lower than that in the treatment group. (b) qRT-PCR revealed that mRNA levels of TNF-<i>α</i> and IL-1<i>β</i> were highly decreased after treatment, while anti-inflammatory factor and IL-10 were increased <i>in vivo</i>. 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Stem Cells International

fig6

Figure 6

Figure 6: Mesenchymal Stem Cell-Derived Extracellular Vesicles for Corneal Wound Repair 