Long-Lasting Anti-Inflammatory Activity of Human Microfragmented Adipose Tissue

<div>MFAT-CM inhibits RANTES and MCP-1 secretion by U937. CMs were recovered at 3, 7, 14, and 28 days from MFAT and LP specimens cultured in DMEM serum-free medium and added to U937cells at 1 : 2 dilution. The cells were incubated for 48 h and then medium was recovered to evaluate RANTES (a) and MCP-1 (b) concentration. Experiments were repeated in the presence of LPS (c, d) that stimulate secretion of both chemokines by U937. MFAT-CM resulted able to inhibit the secretion of RANTES and MCP-1 by U937 even in the presence of LPS (1 <i>μ</i>g/ml) stimuli. 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Stem Cells International

fig5

Figure 5

Figure 5: Long-Lasting Anti-Inflammatory Activity of Human Microfragmented Adipose Tissue 