Molecular Profiles of Cell-to-Cell Variation in the Regenerative Potential of Mesenchymal Stromal Cells

Figure 1

Applications of molecular profiles of MSC heterogeneity. Surface markers and global signatures identify cell subsets with specific regenerative properties in heterogeneous MSC cultures. Molecular profiles of MSC heterogeneity have application as molecular targets and quality attributes in the production of MSC therapeutics. Targeted molecules can be regulated by small-molecule and biologic pharmaceuticals, as well as by precision gene editing. Quality attributes enable enrichment of a MSC population and its assessment during all stages of biomanufacturing of MSC therapies from cell isolation to culture expansion to storage. This control over the composition and function of MSC therapies has the potential to improve treatment outcomes for patients.