Chemotherapeutic Stress Induces Transdifferentiation of Glioblastoma Cells to Endothelial Cells and Promotes Vascular Mimicry

<div>Recurrent PDX GBM43 tumors contain elevated tumor-derived vessels. Recurrent PDX GBM43 was established as described. (a) Brains containing tumors were removed and subjected to immunofluorescence (IF) analysis for CD105 with an antibody specific to the human antigen, a marker of intermediate endothelial cells and laminin, which indicates functional vessels. Tumors were identified via DAPI nuclear staining. (b) IF staining for CD31, a marker of mature endothelial cells and laminin. Images taken at 20x magnification.</div>

Stem Cells International

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Figure 6

Figure 6: Chemotherapeutic Stress Induces Transdifferentiation of Glioblastoma Cells to Endothelial Cells and Promotes Vascular Mimicry 