The Biguanides Metformin and Buformin in Combination with 2-Deoxy-glucose or WZB-117 Inhibit the Viability of Highly Resistant Human Lung Cancer Cells

Figure 8

Effect of low concentrations of metformin (MET) and buformin (BUF) alone or in combination with WZB-117 (WZB) on cell cycle distribution. H460 cells were treated with the indicated concentration of drugs for 24 h and then evaluated by flow cytometry as described in Materials and Methods (a-b). (c) Expression of S-phase markers (CDK2 and cyclin E) in H460 cells treated for 24 h with the indicated concentration of drugs.

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(b)

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