CTGF Attenuates Tendon-Derived Stem/Progenitor Cell Aging

<div>Expression of CTGF in TSPCs. (a, b) Heat map and volcano plot showed genes that were differentially expressed between young and old TSPCs. (c) Venn diagram suggested that CTGF is associated with aging, cell differentiation, migration, ECM, and proliferation in TSPCs. (d) Immunofluorescence staining for CTGF in young and aged TSPCs. (e) Protein levels of CTGF are evaluated by western blotting in TSPCs obtained from 4-, 8-, and 20-month-old rats. (f) CTGF mRNA levels were examined by qRT-PCR. (g) Inverse expressions of CTGF and p16<sup>INK4A</sup> were assessed by qRT-PCR. (h) Inverse correlation of CTGF and p16<sup>INK4A</sup> expression levels during expansion and passaging of TSPCs. Scale bars: 20 <i>μ</i>m. 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Stem Cells International

CTGF Attenuates Tendon-Derived Stem/Progenitor Cell Aging

Figure 1