Emerging Role of Mesenchymal Stromal Cell-Derived Extracellular Vesicles in Pathogenesis of Haematological Malignancies

Figure 4

Differences between cargos of extracellular vesicles (EV) derived from multipotent mesenchymal stromal cells (MSC-EV) and tumor-EV in haematological malignancies. MSC-EV from patients with acute myeloid leukaemia, multiple myeloma, and myelodysplastic syndromes are enriched with TGF-β1, CCL2, IL-6, fibronectin, miR-375, miR-340, and miR-155. In several haematological malignancies, tumor-EV cargo reveals high amounts of TGF-β1 and IL-8 and the microRNAs miR-21, miR-146, miR-150, miR-155, miR-340, and miR-375.