Mesenchymal Stem Cells Alleviate Moderate-to-Severe Psoriasis by Reducing the Production of Type I Interferon (IFN-I) by Plasmacytoid Dendritic Cells (pDCs)
MSC infusion ameliorated psoriatic symptoms in IMQ-induced mice. (a) Experimental protocols showing treatment regimens using hUC-MSCs in psoriatic mice. (b) Typical presentation of the mouse back skin for 13 day regimens was shown. (c) The changes of PASI score in psoriatic mice for 13 days. (d) Phenotypical presentation of the mouse back skin represented by gross images, H&E staining, and K16+ immunolabelling. (e) Measurements of the PASI score and epidermal thickness of the mouse back skin. Scale bar, 100 μm. Data was represented as .#,##, and ### (control group vs. the untreated group in all cases); and (untreated group vs. the MSC-treated group).