A Noninvasive Imaging Toolbox Indicates Limited Therapeutic Potential of Conditionally Activated Macrophages in a Mouse Model of Multiple Organ Dysfunction

Figure 5

Histological analyses from both the kidney and liver. Histological analyses show sections from typical sections of a kidney from a healthy mouse (a), the kidney of a mouse which had received adriamycin (b), the liver of a healthy mouse (c), and the liver of a mouse which had received adriamycin (d1, d2). All organs were collected on day 4 of the study and were stained with haematoxylin and eosin. (a) and (b) scale  μm. (c) and (d) scale  μm. No evidence of injury is observed in (a) or (c). (b) shows evidence of intratubular protein casts and flattening of the tubular epithelium (arrow). (d1) shows evidence of hepatocellular degeneration (arrow) and (d2) shows evidence of necrosis with evidence of pale eosinophilic substance. Histological scoring for the kidney and liver is shown (e and f, respectively). Each data point represents an individual animal.

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