A Review on the Effect of Plant Extract on Mesenchymal Stem Cell Proliferation and Differentiation

Table 1

Effect of plant extract on MSC proliferation.

Plant	MSC source	Mechanism of action	References
Epimedium pubescens (TCM)	hBMSCs	20 μg/ml increases significant proliferation	[96]
Glycine max var. (vegetable soy peptides)	hAD-MSCs and CB-MSCs	25% and 20% increase cell proliferation rate, and TGF-β1 plays a crucial role to induce proliferation	[97]
Ocimum basilicum	hDP-MSCs and BM-MSC	Induces MSC proliferation and reduces doubling time (DT) at 10 μg/ml concentration	[98]
Paullinia cupana (guaraná)	hAD-MSCs	5 and 10 mg/ml concentrations stimulate proliferation. Increases the catalase (CAT) activity and SOD2, CAT, and GPx gene expression	[99]
Glycyrrhiza glabra (licorice root)	hBM-MSC	Increases significant level of proliferation at concentration 10-50 μg/ml	[100]
Thymbra spicata var. intricata	h-Dental pulp (DP) and BM-MSCs	Reduces the doubling time (DT) at 10 μg/ml for MSCs and acts as a good proliferation inducer	[101]
ZD-I: TCM	Telomerized hMSCs	0.78–25 μg/ml stimulates the proliferation	[102]
Rhizoma drynariae	hBM-MSC	0–200 μg/ml concentration of the naringin solution enhances the proliferation	[93]
Foeniculum vulgare	hBM-MSC	Proliferation activity is seen with a dose of 5 μg/ml	[103]
Cissus quadrangularis (Linn.)	Wistar rat BM-MSCs	300 μg/ml concentration increases the proliferation rate by 2-fold	[91]
Apple	h-AD MSCS and CB-MSCs	Proliferation promotes by ERK-dependent cytokine production	[104]
Ferula gummosa	hBM-MSCs	0.5 to 5 μg/ml increases significant cell proliferation	[105]
Ginkgo biloba	hBM-MSCs	25 mg/l increases the cell proliferation by 30%	[106]