Palmitic Acid Methyl Ester Induces G₂/M Arrest in Human Bone Marrow-Derived Mesenchymal Stem Cells via the p53/p21 Pathway

Figure 7

Schematic representation of the PAME-induced G₂/M arrest in hBM-MSCs. PAME decreased the expression of Mdm2, which in turn reduced the degradation of p53, subsequently upregulating the expression of Cdk1 and cyclin B1 through suppression of the p21 protein level, and eventually caused cell cycle arrest at the G₂/M phase.