Neuronal Transdifferentiation Potential of Human Mesenchymal Stem Cells from Neonatal and Adult Sources by a Small Molecule Cocktail

<div>Presence of mature neuronal markers after induction with ICFRYA plus neurotrophic factors and FBS in UCB- and BM-MSCs. (a, b) Representative pictures of TUJ1, MAP2, TAU, NF-H, GABA B, ENO2, and NeuN positive cells after neuronal induction. The images on A show the merge, and the images on B and C show the individual signal for each antibody. (a) BM-MSCs after 8 days of induction and (b) UCB-MSCs after 4 days of induction. (c) Quantification of cells positive for the neuronal markers induced by the ICFRYA cocktail plus neurotrophic factors. 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Scale bars represent 100 <i>μ</i>m.</div>

Stem Cells International

fig3

Figure 3

Figure 3: Neuronal Transdifferentiation Potential of Human Mesenchymal Stem Cells from Neonatal and Adult Sources by a Small Molecule Cocktail 